Table 2, Statistics over 42 structure-function classes

This table shows various totals from Figure 2 distributed among the 42 structure-function classes -- i.e. the seven functional categories in Table 1A multiplied by the six structural categories in Table 1B. Part A shows how many potential fold-function combinations there are in Figure 2 amongst each of the 42 classes. Part B shows how many of these 21068 possible combinations are actually observed. Part C shows the total number of different folds (i.e. selected columns in figure 1) in each class. Part D shows the total number of different functions (i.e. selected rows in Figure 2) in each class. Part E shows the total number of matching Swissprot proteins in the 42 classes. Note that to observe a fold-function combination one only needs the existence of a single match between a Swissprot protein and a SCOP domain. However, there can be many more. That is why the totals in table sum up to so much larger an amount than 331.

Here is an example of how to read the table, focussing on the all-alpha, oxidoreductase region. Part A shows that there are 1104 cells, filled or unfilled, in this region, corresponding to possible combinations. Part B shows that 13 of these 1104 cells are filled, corresponding to observed all-alpha, oxidoreductase combinations. Part C shows that there are 7 folds, corresponding to columns with filled cells in this region. Part D shows that there are 8 functions, corresponding to rows with filled cells in this region. Finally, in Part E we find that there are 150 Swissprot entries that have matches with a SCOP domain. They correspond to the 13 observed combinations in Part B.

A. Number of possible combinations between folds and functions in each of 42 classes (number of cells in Figure 2)
 A B A/B A+B MULTI SML sum NONENZ 46 36 48 56 15 28 229 OX 1104 864 1152 1344 360 672 5496 TRAN 598 468 624 728 195 364 2977 HYD 1334 1044 1392 1624 435 812 6641 LY 414 324 432 504 135 252 2061 ISO 460 360 480 560 150 280 2290 LIG 276 216 288 336 90 168 1374 sum 4232 3312 4416 5152 1380 2576 21068

B. Number of observed combinations between folds and functions in each of 42 classes (number of filled cells in Figure 2)
 A B A/B A+B MULTI SML sum NONENZ 34 30 14 28 4 26 136 OX 13 5 17 3 4 5 47 TRAN 3 3 16 8 5 35 HYD 4 11 30 18 4 67 LY 2 3 13 5 23 ISO 1 2 7 4 2 16 LIG 1 2 3 1 7 sum 57 55 99 69 20 31 331

C. Number of folds in each of the 42 classes (columns with a filled cell in Figure 2)

 A B A/B A+B MULTI SML sum NONENZ 34 30 14 28 4 26 136 OX 7 5 9 3 3 3 30 TRAN 3 2 15 6 5 31 HYD 4 8 19 18 3 52 LY 2 3 8 5 18 ISO 1 2 7 4 2 16 LIG 1 1 3 1 6 sum 51 51 73 67 18 29 289

D. Number of functions in each of the 42 classes (rows with a filled cell in Figure 2)

 A B A/B A+B MULTI SML sum NONENZ 1 1 1 1 1 1 6 OX 8 5 9 3 3 5 33 TRAN 2 3 13 8 4 30 HYD 4 7 19 14 4 48 LY 2 2 7 3 14 ISO 1 2 5 4 1 13 LIG 1 2 2 1 6 sum 18 21 56 35 14 6 150

E. Total number of matching Swissprot sequences in each of the 42 fold-function classes

 A B A/B A+B MULTI SML sum NONENZ 1940 1159 560 638 106 892 5295 OX 150 202 388 50 68 18 876 TRAN 65 14 363 116 174 732 HYD 116 394 295 452 92 1349 LY 40 47 168 104 359 ISO 2 54 122 22 2 202 LIG 5 26 69 24 124 sum 2313 1875 1922 1451 466 910 8937

© 1998 Hedi Hegyi & Mark Gerstein
© 1998 Graphics - Jimmy Lin