Figure 6, Multi-functionality versus e-value threshold
The graph shows how the percentage number of multifunctional enzymatic domains varies as the function of the e-value threshold. A multi-functional domain occurs when a particular domain in SCOP matches domains in Swissprot with different enzymatic function. For these calculations, we had to use a more minimal version of scop than the pdb95d dataset referred to in the methods to prevent double matches -- i.e. two scop domains matching a single Swissprot domain. The construction of this minimal scop was described previously . Basically, all the domains in scop were clustered via a multi-linkage approach into 990 representative domains, such that no two domains matched each other with a FastA e-value better than .01.
© 1998 Hedi Hegyi & Mark Gerstein
© 1998 Graphics - Jimmy Lin