Figure 1: Specific Example of Convergent Evolution
The following shows an example of convergent evolution, structures of two carbonic anhydrases with the same enzymatic function (EC number 18.104.22.168) but with different folds. Drawn with Molscript from 1THJ (left handed beta helix) and 1DMX (flat beta sheet).
Figure 1: Specific Example of Divergent Evolution
The following shows an example of possible divergent evolution, the TIM barrel. This fold functions as a generic scaffold catalyzing 15 different enzymatic functions. A schematic figure of the TIM barrel fold is shown with numbers indicating the different location of the active site in four proteins that have this fold. These four proteins -- xylose isomerase, aldose reductase, enolase, and adenosine deaminase -- carry out very different enzymatic functions, in four of the main EC classes (1.*.*, 3.*.*, 4.*.*, and 5.*.*).
© 1998 Hedi Hegyi & Mark Gerstein
© 1998 Graphics - Jimmy Lin