File name: sprot37_hc.tma File description: collection of sequences corresponding to all TRANSMEM annotatations in Swiss-Prot, rel. 37 and updates until March 17, 1999, after homology removal. 13,606 TM records. File type: text file, tab separated 1) Swiss-Prot protein ID 2) Serial number of TM annotation in protein sequence 3) Total number of TM annotations in protein squence 4) Position in protein sequence of the first residue of the TM annotation 5) Position in protein sequence of the last residue of the TM annotation 6) N-terminal sequence before TM (12 residues) 7) TM sequence 8) C-terminal sequence after TM (12 residues) 9) Potential flag: 'Y' = protein is potential (ORF, protein ID starts with Y) 'P' = annotation marked with POTENTIAL, PROBABLE or POSSIBLE 'S' = annotation marked with BY SIMILARITY ' ' = none of the above 10) Hydrophobicity (GES scale) of the most hydrophobic 18-residues window around the annotation, found in a range including the TM and flaking regions up to 30 residues. 11) Position in protein sequence of the first residue of the most hydrophobic 18-residues window Reference: Senes A., Gerstein M. and Engelman D.M. "Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions." J.Mol.Biol. (2000) vol. 296(3), pages 921-936 URLs: http://engelman.csb.yale.edu/tmstat/ http://bioinfo.mbb.yale.edu/tmstat/