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Bioinformatics Module, Survey, "Demographics", Projects, Intro. lecture [html] [pdf], Sequences lectures [html] [pdf], Databases lectures [html] [pdf], Structures lectures [html] [pdf], Simulation lectures [html] [pdf]
Genomics describes the determination of the nucleotide sequence as well as many further analyses used to discover functional and structural gene information on all the genes of an organism. Topics include the methods and results of analysis on a genome-wide scale as well as a discussion of the implications of this research. Bioinformatics describes the computational analysis of gene sequences and protein structures on a large scale. Topics include sequence alignment, biological database design, geometric analysis of protein structure, and macromolecular simulation. [Blue Book Entry]
This course can either be taken as an integrated semester-long course (452a) or as separate modules in genomics (752a1) and bioinformatics (752a2, starting 18 October).
Meeting from 1:00-2:15 PM on Mondays and Wednesday, in Bass 305.
First meeting: Bass 305, 1:00-2:15 PM, Wednesday 1 September 1999.
MB&B Department, Bass
building, Yale University, New Haven, CT
06520
Genomics Module, 752a1
Dieter Söll
Bass 238, Phone 203 432-6200, e-mail dieter.soll@yale.edu
Handouts and readings with Ava Artaiz <ava.artaiz@yale.edu>
Bass 238, 203 432-6203.
Michael
Snyder
KBT 926, Phone 203 432-6139, e-mail michael.snyder@yale.edu
Bioinformatics Module, 752a2
Mark Gerstein
Bass 432A, Phone 203 432-6105, e-mail Mark.Gerstein@yale.edu
Handouts and readings with Joann Delvecchio <joann.delvecchio@yale.edu>
J W Gibbs 309C, 203 432-5566.
Material for the bioinformatics module, including on-line lectures, readings, assignments, and survey will be at
bioinfo.mbb.yale.edu/mbb452a/bioinformatics.htmCourse e-mail list at class@bioinfo.mbb.yale.edu with Hypertext archive of course messages
The bioinformatics module will follow a very similar progression to the course offered last spring.
(See, in particular, http://bioinfo.mbb.yale.edu/course/classes.)Also, see other related on-line lectures.
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| Sep | 01 | DS | The diversity of life (Life at 105°C or at pH 1 or at 5M KCI) |
| 06 | DS | Overview of Proteins & Nucleic Acids | |
| 08 | DS | Physical and genetic maps; whole genome sequences | |
| 13 | DS | Tools of bioinformatics for genomics | |
| 15 | DS | Functional genomics I (array technologies & uses) | |
| 20 | MS | Functional genomics II (gene disruptions, fusions) | |
| 22 | DS | Proteomics | |
| 27 | DS | Structural genomics | |
| 29 | DS | Genome comparisons | |
| Oct | 04 | DS | Genomics: an industrial perspective (Carl Simmons, Pioneer Hi-Bred) |
| 06 | DS | Genomics: a scientific and user's perspective | |
| 08 | DS | Genomics: a societal perspective (Madeline Baer, SkaddenArps) | |
| 13 | DS | MIDTERM EXAM (covering lectures through October 06) | |
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| 18 | MG | What is Bioinformatics? | |
| 20 | MG | Sequence Alignment I (via Dynamic Programming) | |
| 25 | MG | Sequence Alignment II | |
| 27 | MG | Sequence Alignment III (Scoring Schemes) | |
| Nov | 01 | MG | Sequence Alignment IV |
| 03 | MG | Macromolecular Geometry I (Structural Alignment & Threading) | |
| 08 | MG | Macromolecular Geometry II (Surfaces & Volumes) | |
| 10 | MG | Databases I | |
| 15 | MG | Databases II | |
| 17 | MG | Databases III (Trees, multiple alignment) | |
| 29 | MG | Macromolecular Geometry III (Docking, simulation) | |
| Dec | 01 | MG | Summary (societal and industrial perspectives) |
If you're really motivated, take a look at http://bioinfo.mbb.yale.edu/jobs.
The DNA-mouse image is adapted from the GCB-98
homepage. What's wrong with the adaptation?
