Meeting from 1:00-2:15 PM on Mondays and Wednesday, in Bass 305.
: Bass 305, 1:00-2:15 PM, Wednesday 6 September 2000.
MB&B Department, Bass building, Yale University, New Haven, CT 06520
Gibbs 370, e-mail Vadim.Alexandrov@yale.edu
Genomics describes the determination of the nucleotide sequence as well as many further analyses used to discover functional and structural gene information on all the genes of an organism. Topics include the methods and results of analysis on a genome-wide scale as well as a discussion of the implications of this research. Bioinformatics describes the computational analysis of gene sequences and protein structures on a large scale. Topics include sequence alignment, biological database design, geometric analysis of protein structure, and macromolecular simulation. [Blue Book Entry]
|Sep||06||MG||Overview of Bioinformatics [html] [pdf]|
|11||DS||Genomics: Overview. The diversity of life (Life at 105°C, at pH 1 or in 5M KCl)|
|13||DS||Genomics: Overview of Proteins & Nucleic Acids|
|18||DS||Physical and genetic maps. Whole genome sequences|
|20||DS||Whole genome sequences; annotation|
|25||DS||Functional genomics I (array technologies & uses)|
|Oct||02||MS||Functional genomics II (gene disruptions, fusions, etc)|
|04||MS||Functional genomics II contd.|
|09||DS||SNPs, Human Genetic Diversity, Drug Development (Uli Thomann, Genome Therapeutics)|
|11||DS||Structural genomics. Whole genome comparisons|
|16||DS||Agricultural genomics (Carl Simmons, Pioneer Hi-Bred)|
|18||DS||MIDTERM EXAM (covering lectures through October 06)|
|23||MG||Sequence Alignment I (via Dynamic Programming)|
|25||MG||Sequence Alignment II|
|30||MG||Web resources for bioinformatics|
|Nov||01||MG||Multiple alignment and HMMs|
|06||MG||Macromolecular Geometry I (Structural Alignment and Threading)|
|08||DS||Genomics and Society|
|13||MG||Bioinformatics in Society|
|15||MG||Databases and Integrative Analysis I|
|27||MG||Databases and Integrative Analysis II|
|29||MG||Databases and Integrative Analysis III|
|Dec||04||MG||Macromolecular Geometry II|
|06||MG||Macromolecular Geometry III|
If you're really motivated, take a look at http://bioinfo.mbb.yale.edu/jobs.
The DNA-mouse image is adapted from the GCB-98
homepage. What's wrong with the adaptation?
Bioinformatics section, Survey, "Demographics", Projects, Intro. lecture [html] [pdf], Sequences lectures [html] [pdf], Databases lectures [html] [pdf], Structures lectures [html] [pdf], Simulation lectures [html] [pdf]