Molecular Biophysics & Biochemistry 447b3 / 747b3Bioinformatics

What is Bioinformatics?

Administrative

Specific Course Topics -- Sequences

Course Topics -- Structures

Course Topics -- Databases

Are They or Aren’t They Bioinformatics? (#1)

Are They or Aren’t They Bioinformatics? (#1, Answers)

Are They or Aren’t They Bioinformatics? (#2)

Are They or Aren’t They Bioinformatics? (#2, Answers)

Are They or Aren’t They Bioinformatics? (#3)

Are They or Aren’t They Bioinformatics? (#3, Answers)

Major Application I:Designing Drugs

Major Application II:Overall Genome Characterization

Major Application III:Finding Homologues

Major Application III:Finding Homologues (cont.)

Molecular Biology Information: Protein Sequence

Aligning Text Strings

Dynamic Programming

Step 1 -- Make a Dot Plot (Similarity Matrix)

Step 2 -- Start Computing the Sum Matrix

Step 3 -- Keep Going

Step 4 -- Sum Matrix All Done

Step 5 -- Traceback

Step 6 -- Alternate Tracebacks