Molecular Biophysics & Biochemistry 447b3 / 747b3 Bioinformatics

Aligning Text Strings

Step 5 -- Traceback

The Score

What does a Score of 10 mean?

Score in Context of Other Scores

P-value in Sequence Matching

Objective is to Find Distant Homologues

What Distribution Really Looks Like

Extreme Value Distribution Fits

Explicit Form of the P-value in terms of Extreme Value Distribution

Significance Depends on Database Size

Low-Complexity Regions

Practical Issues