Index of /hyper/mbg/ISMB-94-60

      Name                    Last modified       Size  Description


[DIR] Parent Directory        22-Jun-1997 16:01      -  
[TXT] GlobinCore73.dat        08-Jul-1994 13:10    35k  
[CMP] ISMB-94-60.Final.Mac..> 27-May-1994 02:08   147k  
[CMP] ISMB-94-60.Final.Mac..> 27-May-1994 02:06   132k  
[CMP] ISMB-94-60.Final.ps.Z   27-May-1994 02:12   259k  
[TXT] README                  22-Sep-1994 23:13     1k  
[TXT] ToTopLevel.html         22-Aug-1994 01:39     1k  
[   ] core+noncore.tiff                              -  

=========
Reference
=========

R Altman & M Gerstein (1994). "Finding an average core structure:
Application to the globins", Proceedings of the Second International
Conference on Intelligent Systems in Molecular Biology (August 1994,
AAAI Press, Menlo Park, CA).

========
Abstract
========

We present a procedure for automatically identifying from a set of
aligned protein structures a subset of atoms with only a small amount
of structural variation, i.e. a core.  We apply this procedure to the
globin family of proteins. Based purely on the results of the
procedure, we show that the globin fold can be divided into two parts.
The part with greater structural variation consists of the residues
near the heme (the F helix and parts of the G and H helices), and the
part with lesser structural variation (the core) forms a structural
framework similar to that of the repressor protein (A, B, and E
helices and remainder of the G and H helices). Such a division is
consistent with many other structural and biochemical findings. In
addition, we find further partitions within the core that may have
biological significance. Finally, using the structural core of the
globin family as a reference point, we have compared structural
variation to sequence variation and shown that a core definition based
on sequence conservation does not necessarily agree with one based on
structural similarity.