5.3.1.9 4.1.2.13 5.3.1.1 1.2.1.12 2.7.2.3 5.4.2.1 4.2.1.11 1.1.1.49 1.1.1.44 5.1.3.1 5.3.1.6 2.2.1.1 4.1.3.7 4.2.1.3 1.1.1.42 1.3.9.91 4.2.1.2 1.1.1.37 Pathway View

ENZYME: 2.7.2.3 2.7.2.3 FLUX VALUES Flux variation (Standard deviation):14.911 Flux BSUB ECOL HPYL HINF SCER Normal 168 150 70 140 170.9 Absolute 1.68 15.7 70 140 170.92 Seq ID bsupgk ecob2926 hpyHP1345 hinHI0525 sceYCR012W PERCENTAGE IDENTITY Average PID: 0.608 % ID BSUB ECOL HPYL HINF SCER BSUB 1.000 0.477 0.447 0.485 0.484 ECOL 0.477 1.000 0.416 0.813 0.399 HPYL 0.447 0.485 1.000 0.416 0.401 HINF 0.485 0.813 0.399 1.000 0.394 SCER 0.484 0.399 0.401 0.394 1.000 EXPRESSION DATA Multi-scale Reference: 223 copies per cell Standard Deviation of Expression Change Experiment cellcycle_cdc15 cellcycle_alpha diaux yeast_sporu ecoli_UV worm average STDEV 0.374 0.223 0.330 0.751 0.353 0.580 0.435 Average of Expression Change Experiment cellcycle_cdc15 cellcycle_alpha diaux yeast_sporu ecoli_UV worm average stdev STDEV -0.110 0.449 0.361 -0.808 0.364 0.760 0.169 0.554 EXPRESSION TIMEPOINTS Mitotic Cell Cycle [normalized transcript level divided by mean value] link 0 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 1097 1527 2413 1291 1293 1222 2249 1323 1224 5189 2738 1882 1422 2819 3843 3424 2519 Alpha Factor Arrest Synchronization [log2(ratio of mRNA levels)] link 0 7 14 21 28 35 42 49 56 63 70 77 84 91 98 105 112 119 0.46 -0.07 0.27 0.07 0.06 -0.16 0.3 0.1 0.24 -0.05 -0.08 -0.38 -0.01 -0.03 -0.07 -0.08 -0.27 -0.3 CDC15 Synchronization [log2(ratio of mRNA levels)] link 10 30 50 70 80 90 100 110 120 130 140 150 160 -1 -1.81 -1.81 -0.55 0.04 -0.05 0.11 0.1 0.74 0.2 0.25 0.16 0.51 170 180 190 200 210 220 230 240 250 270 290 0 -0.31 0.26 0.91 0.56 1.01 -0.17 0.58 -0.13 0.29 0.1 CDC28 (Stanford) [log2(ratio of mRNA levels)] 0 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 -0.85 -0.38 0.28 -0.62 -0.62 -0.7 0.18 -0.58 -0.7 1.39 0.47 N/A -0.48 0.51 0.96 0.79 0.35 Elutration Synchronization [log2(ratio of mRNA levels)] link 0 30 60 90 120 150 180 210 240 270 300 330 360 390 0.37 0.32 0.27 0.5 0.01 -0.4 -0.75 -0.43 -0.19 0.813 0.47 N/A -0.48 0.51