5.3.1.9 4.1.2.13 5.3.1.1 1.2.1.12 2.7.2.3 5.4.2.1 4.2.1.11 1.1.1.49 1.1.1.44 5.1.3.1 5.3.1.6 2.2.1.1 4.1.3.7 4.2.1.3 1.1.1.42 1.3.9.91 4.2.1.2 1.1.1.37 Pathway View

ENZYME: Norm_flux Norm_flux FLUX VALUES Flux variation (Standard deviation): Flux BSUB ECOL HPYL HINF SCER Normal Norm_flux Norm_flux Norm_flux abs_flux abs_flux Absolute abs_flux abs_flux abs_flux PID PID Seq ID REFERENCE SEQID SEQID SEQID CHO PERCENTAGE IDENTITY Average PID: % ID BSUB ECOL HPYL HINF SCER BSUB 1.000 PID PID PID PID ECOL PID 1.000 PID PID PID HPYL PID PID 1.000 SEQID SEQID HINF PID PID PID 1.000 PID SCER PID PID SEQID PID 1.000 EXPRESSION DATA Multi-scale Reference: CHO copies per cell Standard Deviation of Expression Change Experiment cellcycle_cdc15 cellcycle_alpha diaux yeast_sporu ecoli_UV worm average STDEV std std std std std avg avg Average of Expression Change Experiment cellcycle_cdc15 cellcycle_alpha diaux yeast_sporu ecoli_UV worm average stdev STDEV avg avg avg avg avg avg std avg EXPRESSION TIMEPOINTS Mitotic Cell Cycle [normalized transcript level divided by mean value] link 0 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 CHO CHO CHO CHO CHO CHO CHO CHO CHO CHO CHO CHO CHO CHO CHO Stanford Stanford Alpha Factor Arrest Synchronization [log2(ratio of mRNA levels)] link 0 7 14 21 28 35 42 49 56 63 70 77 84 91 98 105 112 119 Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford CDC15 Synchronization [log2(ratio of mRNA levels)] link 10 30 50 70 80 90 100 110 120 130 140 150 160 Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford 170 180 190 200 210 220 230 240 250 270 290 Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford CDC28 (Stanford) [log2(ratio of mRNA levels)] 0 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 160 Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Elutration Synchronization [log2(ratio of mRNA levels)] link 0 30 60 90 120 150 180 210 240 270 300 330 360 390 Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford Stanford PID Stanford Stanford Stanford Stanford