YaleGerstein Lab Parts ListGeneCensusMolecular MovementsNESG helpdownload

Comparing protein abundance and mRNA expression levels on a genomic scale

Dov Greenbaum, Christopher Colangelo, Kenneth Williams, & Mark Gerstein

Abstract: We survey methods used in determining protein abundance levels (divided into 2D-electrophoresis and mass-spectrometry based methods) and recent attempts to correlate protein abundance and mRNA expression. We discuss the results of these comparisons, focusing on yeast. In the process we merge together much of the available yeast protein abundance data, and use this larger data set to find correlations between protein and mRNA expression data both globally, and in terms of smaller categories of proteins. (TEXT)

(Supplemental information is available at http://bioinfo.mbb.yale.edu/expression/prot-v-mrna/

Supplementary Data Tables:


MALDI-TOF Tutorial
Mass Spectrometry Research Center (MSRC) at the Vanderbilt University Medical Center

Two Dimensional Electrophoresis Tutorial
Dr James R. Jefferies, Institute of Biological Sciences, University of Wales