Experiment: Yeast diauxic shift MIPS Description # ORFs Average corr. X P-value -log(P-value) 08.10 peroxisomal transport 12 0.646 0.00E+00 NA 04.01.04 rRNA processing 53 0.6074 0.00E+00 NA 02.10 tricarboxylic-acid pathway 22 0.5236 0.00E+00 NA 04.07 RNA transport 27 0.5111 0.00E+00 NA 04.01 rRNA transcription 94 0.4998 0.00E+00 NA 08.01 nuclear transport 48 0.4789 0.00E+00 NA 30.19 peroxisomal organization 37 0.466 0.00E+00 NA 04.01.01 rRNA synthesis 38 0.4166 0.00E+00 NA 03.16 DNA synthesis and replication 81 0.3753 0.00E+00 NA 05.04 "translation (initiation, elongation and termination)" 62 0.3674 0.00E+00 NA 01.03.01 purine-ribonucleotide metabolism 42 0.3639 0.00E+00 NA 05.01 ribosomal proteins 182 0.3389 0.00E+00 NA 04.03 tRNA transcription 75 0.3288 0.00E+00 NA 04.05.01.01 general transcription activities 60 0.3099 0.00E+00 NA 03.19 recombination and DNA repair 86 0.2947 0.00E+00 NA 02.13 respiration 69 0.2873 0.00E+00 NA 05 PROTEIN SYNTHESIS 320 0.2777 0.00E+00 NA 30.10 nuclear organization 715 0.2562 0.00E+00 NA 04 TRANSCRIPTION 708 0.2432 0.00E+00 NA 30.03 organization of cytoplasm 545 0.2265 0.00E+00 NA 04.05 mRNA transcrition 511 0.2238 0.00E+00 NA 04.05.01 mRNA synthesis 397 0.223 0.00E+00 NA 03.22 cell cycle control and mitosis 315 0.2213 0.00E+00 NA 03.07 "pheromone response, mating-type determination, sex-specific proteins" 156 0.2171 0.00E+00 NA 03 "CELL GROWTH, CELL DIVISION AND DNA SYNTHESIS" 752 0.2058 0.00E+00 NA 01.01.01 amino-acid biosynthesis 114 0.239 2.00E-04 3.7 01.02.04 regulation of nitrogen and sulphur utilization 28 0.3715 8.00E-04 3.1 02.22 glyoxylate cycle 6 0.8136 1.00E-03 3.0 03.22.01 cell cycle check point proteins 21 0.3741 1.40E-03 2.9 30.16 mitochondrial organization 312 0.1844 2.00E-03 2.7 30.13 organization of chromosome structure 40 0.2991 2.40E-03 2.6 11.04 "DNA repair (direct repair, base excision repair and nucleotide excision repair)" 80 0.2376 2.40E-03 2.6 04.05.05 "mRNA processing (5'-end, 3'-end processing and mRNA degradation)" 36 0.2998 3.00E-03 2.5 06.13.04 lysosomal and vacuolar degradation 17 0.4051 3.20E-03 2.5 05.10 tRNA-synthetases 37 0.3005 3.20E-03 2.5 30.07 organization of endoplasmatic reticulum 113 0.2177 4.60E-03 2.3 04.03.01 tRNA synthesis 23 0.3349 5.60E-03 2.3 04.03.03 tRNA processing 36 0.2708 9.20E-03 2.0 30.04 organization of cytoskeleton 91 0.215 1.06E-02 2.0 08.07 "vesicular transport (Golgi network, etc.)" 98 0.212 1.16E-02 1.9 10.04.11 key kinases 2 0.9403 1.24E-02 1.9 06.13.01 cytoplasmic degradation 93 0.2136 1.24E-02 1.9 03.13 meiosis 92 0.213 1.26E-02 1.9 90 RETROTRANSPOSONS AND PLASMID PROTEINS 7 0.5299 1.30E-02 1.9 03.04 "budding, cell polarity and filament formation" 161 0.1948 1.60E-02 1.8 10.04.13 key phosphatases 2 0.9283 1.64E-02 1.8 03.25 cytokinesis 30 0.2701 1.70E-02 1.8 10.02.07 G-proteins 3 0.8122 2.10E-02 1.7 04.03.99 other tRNA-transcription activities 4 0.6932 2.42E-02 1.6 01.05.07 carbohydrate transport 41 0.2417 2.42E-02 1.6 04.03.06 tRNA modification 12 0.3613 2.54E-02 1.6 09.04 biogenesis of cytoskeleton 17 0.3108 3.00E-02 1.5 30.05 organization of centrosome 27 0.2499 4.26E-02 1.4 06.13 proteolysis 143 0.1832 4.68E-02 1.3 01.20.05 amines metabolism 4 0.5921 5.02E-02 1.3 01.20 secondary metabolism 4 0.5921 5.02E-02 1.3 11.11 ageing 2 0.8634 5.20E-02 1.3 01.01.04 regulation of amino-acid metabolism 32 0.23 5.32E-02 1.3 02.19 "metabolism of energy reserves (glycogen, trehalose)" 37 0.2208 5.88E-02 1.2 10.05.11 key kinases 4 0.5549 6.36E-02 1.2 30.09 organization of intracellular transport vesicles 41 0.2126 7.30E-02 1.1 04.05.03 mRNA processing (splicing) 70 0.1926 7.40E-02 1.1 01.03.16 polynucleotide degradation 20 0.2461 7.50E-02 1.1 01.03.13 regulation of nucleotide metabolism 13 0.2696 9.34E-02 1.0 11.99 other cell rescue activities 9 0.3027 9.48E-02 1.0 01.02 nitrogen and sulphur metabolism 73 0.1869 9.82E-02 1.0 04.05.01.07 chromatin modification 30 0.2121 1.04E-01 1.0 01.07.04 "utilization of vitamins, cofactors, and prosthetic groups " 7 0.3261 1.06E-01 1.0 07.19 allantoin and allantoate transporters 9 0.2864 1.09E-01 1.0 30.08 organization of Golgi 64 0.1855 1.15E-01 0.9 02.01 glycolysis 29 0.2081 1.20E-01 0.9 10.05.99 other pheromone response activities 18 0.2286 1.21E-01 0.9 07.25 ABC transporters 28 0.2083 1.22E-01 0.9 01.03 nucleotide metabolism 134 0.1708 1.23E-01 0.9 10.05 pheromone response generation 34 0.1979 1.28E-01 0.9 01.07 "biosynthesis of vitamins, cofactors, and prosthetic groups " 80 0.1789 1.31E-01 0.9 03.01 cell growth 71 0.1803 1.34E-01 0.9 01.03.10 metabolism of cyclic and unusual nucleotides 8 0.2848 1.39E-01 0.9 07.07 sugar and carbohydrate transporters 44 0.1873 1.40E-01 0.9 01.02.07 nitrogen and sulphur transport 8 0.2829 1.41E-01 0.8 09.08 biogenesis of Golgi 2 0.6647 1.87E-01 0.7 01.07.01 "metabolism of vitamins, cofactors, and prosthetic groups " 60 0.1735 1.94E-01 0.7 09.19 peroxisomal biogenesis 2 0.6512 1.96E-01 0.7 09.13 biogenesis of chromosome structure 17 0.1982 2.16E-01 0.7 08.99 other intracellular-transport activities 22 0.1886 2.29E-01 0.6 04.99 other transcription activities 58 0.1705 2.29E-01 0.6 07.04.01 "metal ion transporters (Cu, Fe, etc.)" 21 0.1824 2.47E-01 0.6 04.05.99 other mRNA-transcription activities 10 0.2058 2.50E-01 0.6 10.02.11 key kinases 8 0.2171 2.50E-01 0.6 01.03.04 pyrimidine-ribonucleotide metabolism 28 0.176 2.50E-01 0.6 06.07 "protein modification (glycolsylation, acylation, myristylation, palmitylation, farnesylation and processing) " 163 0.1566 2.53E-01 0.6 11.07.01 detoxification involving cytochrome P450 4 0.2826 2.58E-01 0.6 13.01 homeostasis of metal ions 55 0.1655 2.72E-01 0.6 01.07.99 "other vitamin, cofactor, and prosthetic group activities " 7 0.2084 2.84E-01 0.5 09.10 nuclear biogenesis 5 0.228 2.90E-01 0.5 08.22 cytoskeleton-dependent transport 27 0.1704 3.05E-01 0.5 10.03.13 key phosphatases 2 0.4928 3.09E-01 0.5 07.04 ion transporters 69 0.1572 3.32E-01 0.5 01.01.99 other amino-acid metabolism activities 4 0.2205 3.34E-01 0.5 03.10 sporulation and germination 97 0.155 3.37E-01 0.5 03.99 "other cell growth, cell division and DNA synthesis activities" 9 0.1643 3.86E-01 0.4 01.04.01 phosphate utilization 13 0.1612 3.88E-01 0.4 02.25 beta-oxidation of fatty acids 6 0.1713 3.89E-01 0.4 01.06.99 "other lipid, fatty-acid and sterol metabolism proteins" 11 0.1561 3.94E-01 0.4 09 CELLULAR BIOGENESIS (proteins are not localized to the corresponding organelle) 163 0.149 3.95E-01 0.4 11.10 cell death 10 0.1586 3.96E-01 0.4 10.02.99 other morphogenetic activities 11 0.1549 3.99E-01 0.4 30.99 other cellular organization 4 0.1687 4.06E-01 0.4 09.07 biogenesis of endoplasmatic reticulum 3 0.193 4.06E-01 0.4 07.04.07 "anion transporters (Cl, SO4, PO4, etc.)" 16 0.1555 4.06E-01 0.4 01.01 amino-acid metabolism 199 0.1488 4.20E-01 0.4 01.06.01 "lipid, fatty-acid and sterol biosynthesis" 94 0.1495 4.31E-01 0.4 10.03.11 key kinases 8 0.1482 4.31E-01 0.4 07.16 purine and pyrimidine transporters 14 0.1433 4.62E-01 0.3 10.02 morphogenesis 27 0.1451 4.68E-01 0.3 06.01 protein folding and stabilization 53 0.1445 4.80E-01 0.3 10.05.07 G-proteins 7 0.1316 4.87E-01 0.3 07.10 amino-acid transporters 25 0.1411 4.88E-01 0.3 01.06.10 "regulation of lipid, fatty-acid and sterol biosynthesis" 19 0.1395 4.89E-01 0.3 07.04.04 "other cation transporters (Na ,K ,Ca ,NH4 ,etc.)" 34 0.1415 5.03E-01 0.3 08.16 extracellular transport 35 0.1379 5.34E-01 0.3 06.13.07 other subcellular degradation 14 0.1265 5.44E-01 0.3 01.04 phosphate metabolism 31 0.1348 5.47E-01 0.3 01.03.19 nucleotide transport 12 0.1187 5.55E-01 0.3 09.01 biogenesis of cell wall 98 0.1399 5.66E-01 0.2 06.04 "protein targeting, sorting and translocation" 115 0.1404 5.84E-01 0.2 01.03.07 deoxyribonucleotide metabolism 12 0.1095 5.94E-01 0.2 06 PROTEIN DESTINATION 511 0.1418 6.06E-01 0.2 10.04.09 regulation of G-protein activity 4 0.0403 6.30E-01 0.2 01.07.10 "transport of vitamins, cofactors, and prosthetic groups " 3 -0.0122 6.31E-01 0.2 01.06.16 lipid and fatty-acid binding 3 -0.0149 6.35E-01 0.2 01.01.07 amino-acid transport 23 0.1198 6.39E-01 0.2 10.04 nutritional response pathway 22 0.119 6.40E-01 0.2 10.05.09 regulation of G-protein activity 2 -0.1221 6.69E-01 0.2 07.01 ion channels 7 0.0658 6.87E-01 0.2 05.99 other protein-synthesis activities 12 0.09 6.93E-01 0.2 05.07 translational control 28 0.1144 6.96E-01 0.2 01.06.04 breakdown of lipids and phospholipids 15 0.0929 7.28E-01 0.1 09.25 vacuolar and lysosomal biogenesis 13 0.0893 7.31E-01 0.1 01.04.07 phosphate transport 10 0.0724 7.39E-01 0.1 01.04.04 regulation of phosphate utilization 8 0.0599 7.41E-01 0.1 10.03 osmosensing 17 0.0957 7.46E-01 0.1 02.99 other energy generation activities 14 0.086 7.55E-01 0.1 10.05.01 receptor proteins 2 -0.3095 7.61E-01 0.1 09.16 mitochondrial biogenesis 9 0.0575 7.69E-01 0.1 02 ENERGY 224 0.1343 7.70E-01 0.1 06.99 other protein-destination activities 5 -0.0034 7.74E-01 0.1 10 SIGNAL TRANSDUCTION 122 0.1273 7.76E-01 0.1 10.04.99 other nutritional-response activities 9 0.0401 8.23E-01 0.1 08.13 vacuolar transport 43 0.1079 8.28E-01 0.1 07.28 drug transporters 34 0.1015 8.42E-01 0.1 30.22 endosomal organization 8 0.0258 8.45E-01 0.1 07.13 lipid transporters 7 0.003 8.59E-01 0.1 01.07.07 "regulation of vitamins, cofactors, and prosthetic groups " 3 -0.2041 8.60E-01 0.1 02.04 gluconeogenesis 12 0.048 8.65E-01 0.1 08.04 mitochondrial transport 68 0.1117 8.67E-01 0.1 10.03.05 mediator proteins 3 -0.2108 8.67E-01 0.1 07.99 other transport facilitators 51 0.1064 8.69E-01 0.1 06.10 assembly of protein complexes 86 0.1142 8.88E-01 0.1 04.01.99 other rRNA-transcription activities 3 -0.2383 8.94E-01 0.0 02.16 fermentation 32 0.0885 8.98E-01 0.0 01.05.04 regulation of carbohydrate utilization 120 0.1174 9.03E-01 0.0 30.25 vacuolar and lysosomal organization 47 0.0971 9.16E-01 0.0 98 CLASSIFICATION NOT YET CLEAR-CUT 147 0.1185 9.24E-01 0.0 10.04.07 G-proteins 3 -0.2712 9.28E-01 0.0 01.03.99 other nucleotide-metabolism activities 7 -0.0328 9.32E-01 0.0 10.02.09 regulation of G-protein activity 5 -0.1121 9.46E-01 0.0 10.03.99 other osmosensing activities 4 -0.1644 9.50E-01 0.0 10.99 other signal-transduction activities 37 0.0799 9.54E-01 0.0 30.01 organization of cell wall 28 0.067 9.61E-01 0.0 11 "CELL RESCUE, DEFENSE, CELL DEATH AND AGEING " 330 0.1215 9.62E-01 0.0 01.06.13 lipid and fatty-acid transport 17 0.0399 9.62E-01 0.0 01.05.99 other carbohydrate metabolism activities 2 -0.8127 9.65E-01 0.0 01.02.01 nitrogen and sulphur utilization 37 0.0726 9.72E-01 0.0 01.06 "lipid, fatty-acid and sterol metabolism" 175 0.1112 9.76E-01 0.0 11.01 stress response 147 0.1088 9.76E-01 0.0 01.06.07 "lipid, fatty-acid and sterol utilization" 26 0.0487 9.82E-01 0.0 02.07 pentose-phosphate pathway 9 -0.0418 9.82E-01 0.0 11.07 detoxificaton 94 0.0969 9.83E-01 0.0 30.90 extracellular/secretion proteins 20 0.0288 9.86E-01 0.0 08.19 cellular import 99 0.0957 9.87E-01 0.0 01.01.10 amino-acid degradation 36 0.0524 9.94E-01 0.0 08 INTRACELLULAR TRANSPORT 415 0.1162 9.96E-01 0.0 13 IONIC HOMEOSTASIS 114 0.0888 9.98E-01 0.0 01 METABOLISM 1005 0.1001 9.98E-01 0.0 30.02 organization of plasma membrane 141 0.0927 9.98E-01 0.0 07 TRANSPORT FACILITATION 290 0.0873 9.98E-01 0.0 01.05 carbohydrate metabolism 409 0.0779 9.98E-01 0.0 01.05.01 carbohydrate utilization 256 0.075 9.98E-01 0.0 13.04 homeostasis of other ions 60 0.042 1.00E+00 0.0 07.22 transport ATPases 38 0.0219 1.00E+00 0.0