What's on the surface of (soluble) proteins?

-Around 50% of atoms on protein surfaces are hydrophobic (not all hydrophobic atoms are burried)

• Lee, B. and Richards, F.M. 1971. J. Mol. Biol. 55:379-400
• Shrake, A. and Rupley, J.A. 1973. J. Mol. Biol. 79:351-371

-Charged atoms and groups are almost always solvent exposed

• Richards, F.M. 1977. Ann. Rev. Biophys. Bioeng. 6:151-76