Molecular Biophysics & Biochemistry 447b3 / 747b3 Bioinformatics

1/28/98


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Table of Contents

Molecular Biophysics & Biochemistry 447b3 / 747b3 Bioinformatics

Aligning Text Strings

Step 5 -- Traceback

The Score

What does a Score of 10 mean?

Score in Context of Other Scores

P-value in Sequence Matching

Objective is to Find Distant Homologues

What Distribution Really Looks Like

Extreme Value Distribution Fits

Explicit Form of the P-value in terms of Extreme Value Distribution

Significance Depends on Database Size

Low-Complexity Regions

Practical Issues

Author: Office97

Email: Mark.Gerstein@Yale.edu

Home Page: http://bioinfo.mbb.yale.edu/course

Other information:
All overheads are copyright 1998, Mark Gerstein, All Rights Reserved