http://bioinfo.mbb.yale.edu/align/src/profiles-code Mark.Gerstein@yale.edu This directory contains some rough routines for calculating the sequence variability in an alignment, in terms of the entropy of various profile columns. It is associated with the calculations in: M Gerstein & R Altman (1995). "Average core structures and variability measures for protein families: Application to the immunoglobulins," Journal of Molecular Biology 251: 161-175. PUBMED-ID: 7643385 http://bioinfo.mbb.yale.edu/e-print/avgstr-jmb.pdf http://bioinfo.mbb.yale.edu/hyper/mbg/AvgCore/ NB: The code in this directory will probably not compile right away. It is meant as more of a collection of samples and guides, rather than a usable program. EntropyTest.c is program that is meant to be linked to many of the routines in the other files.